Dlx transcription factors promote migration through repression of axon and dendrite growth

被引：187

作者：

Cobos, Inma ^{[1
]}

Borello, Ugo ^{[1
]}

Rubenstein, John L. R. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94158 USA

来源：

NEURON | 2007年 / 54卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2007.05.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the mouse telencephalon, DIx homeobox transcription factors are essential for the tangential migration of subpallial-derived GABAergic interneurons to neocortex. However, the mechanisms underlying this process are poorly understood. Here, we demonstrate that DIx1/2 has a central role in restraining neurite growth of subpallial-derived immature interneurons at a stage when they migrate tangentially to cortex. In DIx1(-/-);DIx(2-/-) mutants, neurite length is increased and cells fail to migrate. In DIx1(-/-); DIx2(+/-) mutants, while the tangential migration of immature interneurons appears normal, they develop dendritic and axonal processes with increased length and decreased branching, and have deficits in their neocortical laminar positions. Thus, DIx1/2 is required for coordinating programs of neurite maturation and migration. In this regard, we provide genetic evidence that in immature interneurons DIx1/2 repression of the p21-activated serine/threonine kinase PAK3, a downstream effector of the Rho family of GTPases, is critical in restraining neurite growth and promoting tangential migration.

引用

页码：873 / 888

页数：16

共 60 条

[1] OVEREXPRESSION OF THE NEURAL GROWTH-ASSOCIATED PROTEIN GAP-43 INDUCES NERVE SPROUTING IN THE ADULT NERVOUS-SYSTEM OF TRANSGENIC MICE [J].