Preliminary evaluation of a molecular imprinted polymer for solid-phase extraction of tamoxifen

被引：88

作者：

Rashid, BA

Briggs, RJ

Hay, JN

Stevenson, D

机构：

[1] UNIV SURREY,ROBENS INST,GUILDFORD GU2 5XH,SURREY,ENGLAND

[2] UNIV SURREY,DEPT CHEM,GUILDFORD GU2 5XH,SURREY,ENGLAND

来源：

ANALYTICAL COMMUNICATIONS | 1997年 / 34卷 / 10期

关键词：

D O I：

10.1039/a705884e

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A molecular imprinted polymer, prepared around a tamoxifen template, has been synthesised. The feasibility of using this polymer for solid-phase extraction of tamoxifen from biological samples has been investigated. The results show that the drug can be quantitatively retained and eluted from the polymer using acetonitrile-acetic acid. Experiments with biological fluids indicate that clean traces are obtained for HPLC with UV detection using this type of protocol.

引用

页码：303 / 305

页数：3

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