Phagocytosis: An Immunobiologic Process

被引：611

作者：

Gordon, Siamon ^{[1
,2
]}

机构：

[1] Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Taoyuan 33302, Taiwan

[2] Univ Oxford, Sir William Dunn Sch Pathol, S Parks Rd, Oxford OX1 3RE, England

来源：

IMMUNITY | 2016年 / 44卷 / 03期

关键词：

IMMOBILIZED IMMUNE-COMPLEXES; DENDRITIC CELL-RECEPTOR; APOPTOTIC CELLS; MACROPHAGE RECEPTORS; SCAVENGER RECEPTOR; MYCOBACTERIUM-TUBERCULOSIS; MOLECULAR CHARACTERIZATION; MEDIATED PHAGOCYTOSIS; NADPH OXIDASE; HOST-DEFENSE;

D O I：

10.1016/j.immuni.2016.02.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

It has been a century since the death of Elie Metchnikoff, who championed the role of phagocytosis in cellular immunity. Whereas others had observed the uptake of particles by cells from simple to complex organisms, he grasped its significance in the host response to injury and infection and established a firm basis for our understanding of inflammation and tissue homeostasis. The past century has brought improved tools of cellular and molecular biology to the study of phagocytosis and its contribution to physiological and pathological processes, including receptor function in innate and acquired immunity. In this review, I assess our present knowledge and consider opportunities for future research and therapeutic targeting.

引用

页码：463 / 475

页数：13

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