Mouse Piwi-interacting RNAs are 2′-O-methylated at their 3′ termini

被引：208

作者：

Kirino, Yohei ^{[1
]}

Mourelatos, Zissimos ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Div Neuropathol, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 04期

关键词：

D O I：

10.1038/nsmb1218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.

引用

页码：347 / 348

页数：2

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