Readily accessible 9-epi-amino cinchona alkaloid derivatives promote efficient, highly enantioselective additions of aldehydes and ketones to nitroolefins

被引：255

作者：

McCooey, Seamus H. ^{[1
]}

Connon, Stephen J. ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Sch Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 04期

关键词：

D O I：

10.1021/ol0628006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simple cinchona alkaloid derivatives, available via a one-pot procedure from commercially available starting materials, have been shown to promote highly enantio- and diastereoselective Michael-type addition reactions between enolizable carbonyl compounds and nitroalkenes of broad scope. The influence of both the absolute and relative stereochemistry at C-9 on catalyst performance has also been assessed.

引用

页码：599 / 602

页数：4

共 72 条

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