Qualitative analysis of biochemical reaction systems

被引：103

作者：

Reddy, VN

Liebman, MN

Mavrovouniotis, ML

机构：

[1] NORTHWESTERN UNIV,DEPT CHEM ENGN,EVANSTON,IL 60208

[2] VYSIS INC,DOWNERS GROVE,IL 60515

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 1996年 / 26卷 / 01期

关键词：

Petri nets; biochemical pathways; modeling; discrete event; qualitative analysis; METABOLIC CONTROL-THEORY; ENZYME DEFICIENCY; PETRI NETS;

D O I：

10.1016/0010-4825(95)00042-9

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The qualitative analysis of biochemical reaction systems is presented. A discrete event systems approach is used to represent and analyze bioreaction pathways. The approach is based on Petri nets, which are particularly suited to modeling stoichiometric transformations, i.e. the inter-conversion of metabolites in fixed proportions. The properties and methods for the analysis of Petri nets, along with their interpretation for biochemical systems, are presented. As an example, the combined glycolytic and pentose phosphate pathway of the erythrocyte cell is presented to illustrate the concepts of the methodology.

引用

页码：9 / 24

页数：16