An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation using microwave heating

被引：16

作者：

Hopkins, CR ^{[1
]}

Collar, N ^{[1
]}

机构：

[1] Aventis Pharmaceut, Dept Med Chem, Drug Innovat & Approval, Bridgewater, NJ 08807 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 47期

关键词：

6-substituted-5H-pyrrolo[2,3-b]pyrazine; heteroannulation; palladium; cyclization; microwave;

D O I：

10.1016/j.tetlet.2004.09.152

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b]pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8631 / 8633

页数：3

共 24 条

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