Rapid homogeneous-phase Sonogashira coupling reactions using controlled microwave heating

被引：176

作者：

Erdélyi, M

Gogoll, A

机构：

[1] Uppsala Univ, Dept Organ Chem, S-75121 Uppsala, Sweden

[2] Uppsala Univ, Dept Organ Pharmaceut Chem, S-75123 Uppsala, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 12期

关键词：

D O I：

10.1021/jo0057250

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A microwave-enhanced, rapid and efficient homogeneous-phase version of the Sonogashira reaction is presented. It has been applied to the coupling of aryl iodides, bromides, triflates, and aryl chloride, as well as pyridine and thiophene derivatives with trimethylsilylacetylene. Excellent yields (80-95%) for substrates containing a large variety of substituents in different positions are obtained in 5-25 min.

引用

页码：4165 / 4169

页数：5

共 34 条

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