Increased endometrial thickness in women with hypertension

被引:20
作者
Bornstein, J
Auslender, R
Goldstein, S
Kohan, R
Stolar, Z
Abramovici, H
机构
[1] Carmel Med Ctr, Dept Obstet & Gynecol, IL-34362 Haifa, Israel
[2] Carmel Med Ctr, Dept Nephrol, IL-34362 Haifa, Israel
[3] Carmel Med Ctr, Dept Community Med & Epidemiol, IL-34362 Haifa, Israel
[4] Rappaport Fac Med, Haifa, Israel
关键词
endometrium; hypertension; ultrasonography; endometrial carcinoma; endometrial hyperplasia;
D O I
10.1067/mob.2000.106719
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: We noticed an increase in endometrial thickness in women with hypertension who were treated with a combination of medications, including beta-blockers. The purpose of this study was to examine whether the endometrium of hypertensive women is thicker than that of healthy women and to determine whether endometrial thickening in hypertensive women is directly related to the antihypertensive beta-blocker treatment. STUDY DESIGN: We compared 3 groups of postmenopausal patients as follows: (1) women with a history of essential hypertension treated with a combination of medications, including beta-blockers; (2) women with a history of hypertension treated with a combination of medications that did not include beta-blockers; and (3) healthy women without hypertension. All patients were interviewed and examined, blood tests were performed, and endometrial thickness in the anterior-posterior diameter was measured by vaginal ultrasonography. Among the exclusion criteria were diabetes or an abnormal fasting blood glucose level, obesity hormonal medication or replacement hormonal therapy during the previous 6 months, and a history of hormonal disturbances, infertility, or polycystic ovary syndrome. RESULTS: Of 45 hypertensive women enrolled in the study, 22 were treated with a beta-blocker combination medication and 23 were treated with other antihypertensive medications. They were compared with 25 healthy women. There was no statistically significant difference in endometrial thickness between women treated with medications, including beta-blockers, and those who were treated with other hypotensive agents. Twenty percent of women with hypertension and none of the healthy women had endometrium >5 mm thick (P < .017; odds ratio, 8.22; 95% confidence interval, 1.22-infinity). CONCLUSION: Twenty percent of hypertensive postmenopausal women were found to have increased endometrial thickness; However, we were unable to substantiate an association between the type of treatment administered, whether beta-blockers were included, and the increase in endometrial thickness.
引用
收藏
页码:583 / 587
页数:5
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