Membrane fusion mediated by ricin and viscumin

被引:27
作者
Pohl, P [1 ]
Antonenko, YN
Evtodienko, VY
Pohl, EE
Saparov, SM
Agapov, II
Tonevitsky, AG
机构
[1] Martin Luther Univ, Fak Med, Inst Med Phys & Biophys, D-06097 Halle, Germany
[2] Moscow State Univ, AN Belozersky Inst Physicochem Biol, Moscow 119899, Russia
[3] Inst Genet & Select Ind Microorganisms, Moscow 113545, Russia
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1998年 / 1371卷 / 01期
关键词
fusion; immunotoxin; lipid bilayer; lectin;
D O I
10.1016/S0005-2736(98)00024-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle-vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:11 / 16
页数:6
相关论文
共 36 条
[1]   The role of structural domains in RIP II toxin model membrane binding [J].
Agapov, II ;
Tonevitsky, AG ;
Shamshiev, AT ;
Pohl, E ;
Pohl, P ;
Palmer, RA ;
Kirpichnikov, MP .
FEBS LETTERS, 1997, 402 (01) :91-93
[2]   RIBOSOME-INACTIVATING PROTEINS FROM PLANTS [J].
BARBIERI, L ;
BATTELLI, MG ;
STIRPE, F .
BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1154 (3-4) :237-282
[3]  
BAU MY, 1993, J BIOL CHEM, V268, P19939
[4]  
BEAUMELLE B, 1993, J BIOL CHEM, V268, P23661
[5]   A liposome-based model system for the simulation of lectin-induced cell adhesion [J].
Bendas, G ;
Vogel, J ;
Bakowski, U ;
Krause, A ;
Muller, J ;
Rothe, U .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1997, 1325 (02) :297-308
[6]  
BENTZ J, 1992, STRUCTURE BIOL MEMBR, P915
[7]   TRANSLOCATION OF RICIN A-CHAIN INTO PROTEOLIPOSOMES RECONSTITUTED FROM GOLGI AND ENDOPLASMIC-RETICULUM [J].
BILGE, A ;
WARNER, CV ;
PRESS, OW .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (40) :23720-23725
[8]   IMMUNOTOXINS AGAINST CANCER [J].
BRINKMANN, U ;
PASTAN, I .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01) :27-45
[9]  
CHERNOMORDIK L, 1995, J MEMBRANE BIOL, V146, P1
[10]   MOLECULAR MECHANISM OF INHIBITION OF MAMMALIAN PROTEIN-SYNTHESIS BY SOME 4-CHAIN AGGLUTININS - PROPOSAL OF AN EXTENDED CLASSIFICATION OF PLANT RIBOSOME-INACTIVATING PROTEINS (RIBOSOMAL-RNA N-GLYCOSIDASES) [J].
CITORES, L ;
FERRERAS, JM ;
IGLESIAS, R ;
CARBAJALES, ML ;
ARIAS, FJ ;
JIMENEZ, P ;
ROJO, MA ;
GIRBES, T .
FEBS LETTERS, 1993, 329 (1-2) :59-62