Membrane fusion mediated by ricin and viscumin

被引：27

作者：

Pohl, P ^{[1
]}

Antonenko, YN

Evtodienko, VY

Pohl, EE

Saparov, SM

Agapov, II

Tonevitsky, AG

机构：

[1] Martin Luther Univ, Fak Med, Inst Med Phys & Biophys, D-06097 Halle, Germany

[2] Moscow State Univ, AN Belozersky Inst Physicochem Biol, Moscow 119899, Russia

[3] Inst Genet & Select Ind Microorganisms, Moscow 113545, Russia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1998年 / 1371卷 / 01期

关键词：

fusion; immunotoxin; lipid bilayer; lectin;

D O I：

10.1016/S0005-2736(98)00024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ribosome inactivating plant proteins (RIPs) ricin and viscumin but not Ricinus communis agglutinin are able induce vesicle-vesicle fusion. A model is suggested in which the toxicity of the RIPs is partially determined by their fusogenicity. Herein, fusion is hypothesized to allow the RIPs to leak across endocytic vesicles to approve their access to cytoplasmic ribosomes. (C) 1998 Elsevier Science B.V.

引用

页码：11 / 16

页数：6

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