Performance of a miniaturized bioreactor in space flight: microtechnology at the service of space biology

被引：13

作者：

Walther, I

van der Schoot, B

Boillat, M

Cogoli, A

机构：

[1] Swiss Fed Inst Technol, Space Biol Grp, CH-8005 Zurich, Switzerland

[2] Seyon SA, CH-2000 Neuchatel, Switzerland

来源：

ENZYME AND MICROBIAL TECHNOLOGY | 2000年 / 27卷 / 10期

关键词：

bioreactor; microgravity; yeast; microtechnology; continuous cultivation;

D O I：

10.1016/S0141-0229(00)00300-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We describe here the performance and the use of microtechnology in a miniaturized bioreactor developed for the continuous cultivation of yeast cells, Saccharomyces cerevisiae, in microgravity. This bioreactor has been used on two Shuttle missions, where its functionality was successfully demonstrated. In the future, bioreactors will become a key element for long-term experiments, and would also be applied in the cultivation of mammalian cells or tissues for medical applications. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：778 / 783

页数：6

共 11 条

[1]

BOILLAT MA, 1995, MICRO ELECTRO MECHANICAL SYSTEMS - IEEE PROCEEDINGS, 1995, P350, DOI 10.1109/MEMSYS.1995.472596

[2] DYNAMIC CELL-CULTURE SYSTEM - A NEW CELL CULTIVATION INSTRUMENT FOR BIOLOGICAL EXPERIMENTS IN SPACE [J].

GMUNDER, FK ;

NORDAU, CG ;

TSCHOPP, A ;

HUBER, B ;

COGOLI, A .

JOURNAL OF BIOTECHNOLOGY, 1988, 7 (03) :217-228

[3]

KULESH DD, 1994, J CELL BIOCHEM, V55, P520

[4]

MONTGOMERY POB, 1978, IN VITRO CELL DEV B, V14, P165

[5]

OSER H, 1990, LIFE SCI EXPT FACILI, P43

[6] A PIEZOELECTRIC MICROPUMP BASED ON MICROMACHINING OF SILICON [J].

VANLINTEL, HTG ;

VANDEPOL, FCM ;

BOUWSTRA, S .

SENSORS AND ACTUATORS, 1988, 15 (02) :153-167

[7] Cultivation of Saccharomyces cerevisae in a bioreactor in microgravity [J].

Walther, I ;

Bechler, B ;

Muller, O ;

Hunzinger, E ;

Cogoli, A .

JOURNAL OF BIOTECHNOLOGY, 1996, 47 (2-3) :113-127

[8] DEVELOPMENT OF A MINIATURE BIOREACTOR FOR CONTINUOUS-CULTURE IN A SPACE LABORATORY [J].

WALTHER, I ;

VANDERSCHOOT, BH ;

JEANNERET, S ;

ARQUINT, P ;

DEROOIJ, NF ;

GASS, V ;

BECHLER, B ;

LORENZI, G ;

COGOLI, A .

JOURNAL OF BIOTECHNOLOGY, 1994, 38 (01) :21-32

[9]

Walther I, 1999, CHIMIA, V53, P75

[10]

WALTHER I, 1999, RRD BIOTECH BIOENG 1, V2, P65

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