Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats

被引：84

作者：

Cudalbu, Cristina ^{[1
]}

Comment, Arnaud ^{[1
,3
]}

Kurdzesau, Fiodar ^{[2
]}

van Heeswijk, Ruud B. ^{[1
]}

Uffmann, Kai ^{[1
]}

Jannin, Sami

Denisov, Vladimir ^{[4
]}

Kirik, Deniz ^{[4
]}

Gruetter, Rolf ^{[1
,3
,5
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Funct & Metab Imaging, SB, IPMC,LIFMET, CH-1015 Lausanne, Switzerland

[2] Paul Scherrer Inst, Villigen, Switzerland

[3] Univ Lausanne, Dept Radiol, CH-1015 Lausanne, Switzerland

[4] Lund Univ, BRAINS, Dept Expt Med Sci, Lund, Sweden

[5] Univ Geneva, Dept Radiol, CH-1211 Geneva 4, Switzerland

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2010年 / 12卷 / 22期

基金：

瑞士国家科学基金会;

关键词：

MAGNETIC-RESONANCE SPECTROSCOPY; HUMAN BREAST-LESIONS; NEOADJUVANT CHEMOTHERAPY; HUMAN PROSTATE; BRAIN-TUMORS; CANCER; METABOLISM; C-13; COMPENSATION; PRINCIPLES;

D O I：

10.1039/c002309b

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo C-13 MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized N-15 labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized N-15 labeled choline in live animals.

引用

页码：5818 / 5823

页数：6

共 61 条

[1]

PRINCIPLES OF DYNAMIC NUCLEAR-POLARIZATION [J].