Syntheses of three metabolites of icosapentaenoic and docosahexaenoic acids

被引：10

作者：

Flock, S ^{[1
]}

Skattebol, L ^{[1
]}

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 18期

关键词：

D O I：

10.1039/b004101g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from the n-3 polyunsaturated fatty acids icosapentaenoic acid (1, EPA) and docosahexaenoic acid (2, DHA), the syntheses of methyl 2E,4Z,8Z,11Z,14Z,17Z-icosa-2,4,8,11,14,17-hexaenoate (6), 2E,8Z,11Z,14Z,17Z-icosa-2,8,11,14,17-pentaenoate (7) and 2E,4Z,7Z,10Z,13Z,16Z,19Z-docosa-2,4,7,10,13,16,19-heptaenoate (8), in high stereochemical purity, have been accomplished. The corresponding carboxylic acids have been reported as metabolites in the bioconversion of EPA and DHA.

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页码：3071 / 3076

页数：6

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