Histone modifications in response to DNA damage

被引：83

作者：

Altaf, Mohammed ^{[1
]}

Saksouk, Nehme ^{[1
]}

Cote, Jacques ^{[1
]}

机构：

[1] Univ Laval, Canc Res Ctr, Hotel Dieu, Quebec City, PQ G1R, Canada

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2007年 / 618卷 / 1-2期

基金：

加拿大健康研究院;

关键词：

H2AX; NuA4; Tip60; Ino8o; Swr1; H2AZ;

D O I：

10.1016/j.mrfmmm.2006.09.009

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The packaging of the eukaryotic genome into highly condensed chromatin makes it inaccessible to the factors required for gene transcription, DNA replication, recombination and repair. Eukaryotes have developed intricate mechanisms to overcome this repressive barrier imposed by chromatin. Histone modifying enzymes and ATP-dependent chromatin remodeling complexes play key roles here as they regulate many nuclear processes by altering the chromatin structure. Significantly, these activities are integral to the process of DNA repair where histone modifications act as signals and landing platforms for various repair proteins. This review summarizes the recent developments in our understanding of histone modifications and their role in the maintenance of genome integrity. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：81 / 90

页数：10

共 86 条

[1] Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae [J].

Ahn, SH ;

Cheung, WL ;

Hsu, JY ;

Diaz, RL ;

Smith, MM ;

Allis, CD .

CELL, 2005, 120 (01) :25-36

[2] Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX [J].

Bassing, CH ;

Chua, KF ;

Sekiguchi, J ;

Suh, H ;

Whitlow, SR ;

Fleming, JC ;

Monroe, BC ;

Ciccone, DN ;

Yan, C ;

Vlasakova, K ;

Livingston, DM ;

Ferguson, DO ;

Scully, R ;

Alt, FW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) :8173-8178

[3] Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair [J].

Bird, AW ;

Yu, DY ;

Pray-Grant, MG ;

Qiu, QF ;

Harmon, KE ;

Megee, PC ;

Grant, PA ;

Smith, MM ;

Christman, MF .

NATURE, 2002, 419 (6905) :411-415

[4] Around the world of DNA damage INO80 days [J].

Cairns, BR .

CELL, 2004, 119 (06) :733-735

[5] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].

Celeste, A ;

Fernandez-Capetillo, O ;

Kruhlak, MJ ;

Pilch, DR ;

Staudt, DW ;

Lee, A ;

Bonner, RF ;

Bonner, WM ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2003, 5 (07) :675-U51

[6] Genomic instability in mice lacking histone H2AX [J].

Celeste, A ;

Petersen, S ;

Romanienko, PJ ;

Fernandez-Capetillo, O ;

Chen, HT ;

Sedelnikova, OA ;

Reina-San-Martin, B ;

Coppola, V ;

Meffre, E ;

Difilippantonio, MJ ;

Redon, C ;

Pilch, DR ;

Olaru, A ;

Eckhaus, M ;

Camerini-Otero, RD ;

Tessarollo, L ;

Livak, F ;

Manova, K ;

Bonner, WM ;

Nussenzweig, MC ;

Nussenzweig, A .

SCIENCE, 2002, 296 (5569) :922-927

[7] Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair [J].

Chai, B ;

Huang, J ;

Cairns, BR ;

Laurent, BC .

GENES & DEVELOPMENT, 2005, 19 (14) :1656-1661

[8] Phosphorylation of histone H4 serine 1 during DNA damage requires casein kinase II in S-cerevisiae [J].

Cheung, WL ;

Turner, FB ;

Krishnamoorthy, T ;

Wolner, B ;

Ahn, SH ;

Foley, M ;

Dorsey, JA ;

Peterson, CL ;

Berger, SL ;

Allis, CD .

CURRENT BIOLOGY, 2005, 15 (07) :656-660

[9] Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase [J].

Cheung, WL ;

Ajiro, K ;

Samejima, K ;

Kloc, M ;

Cheung, P ;

Mizzen, CA ;

Beeser, A ;

Etkin, LD ;

Chernoff, J ;

Earnshaw, WC ;

Allis, CD .

CELL, 2003, 113 (04) :507-517

[10] γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair [J].

Chowdhury, D ;

Keogh, MC ;

Ishii, H ;

Peterson, CL ;

Buratowski, S ;

Lieberman, J .

MOLECULAR CELL, 2005, 20 (05) :801-809

← 1 2 3 4 5 6 7 8 9 →