Mouse germ cell development: From specification to sex determination

被引：90

作者：

Ewen, Katherine A. ^{[1
,2
]}

Koopman, Peter ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Div Mol Genet & Dev, Brisbane, Qld 4072, Australia

[2] Univ Newcastle, Sch Environm & Life Sci, Reprod Sci Grp, Newcastle, NSW 2308, Australia

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 323卷 / 01期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

Germ cell; Gonad; Specification; Migration; Proliferation; Epigenetics; Differentiation; Meiosis; Mitotic arrest; LEUKEMIA INHIBITORY FACTOR; X-CHROMOSOME ACTIVITY; TRANSCRIPTIONAL REPRESSOR HBP1; H19 METHYLATION IMPRINT; TESTIS CORD FORMATION; RETINOIC-ACID; IN-VITRO; MEIOTIC PROPHASE; GENE-EXPRESSION; GROWTH-FACTOR;

D O I：

10.1016/j.mce.2009.12.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Primordial germ cells (PGCs) are embryonic progenitors for the gametes. In the gastrulating mouse embryo, a small group of cells begin expressing a unique set of genes and so commit to the germline. Over the next 3-5 days, these PGCs migrate anteriorly and increase rapidly in number via mitotic division before colonizing the newly formed gonads. PGCs then express a different set of unique genes, their inherited epigenetic imprint is erased and an individual methylation imprint is established, and for female PGCs, the silent X chromosome is reactivated. At this point, germ cells (GCs) commit to either a female or male sexual lineage, denoted by meiosis entry and mitotic arrest, respectively. This developmental program is determined by cues emanating from the somatic environment. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：76 / 93

页数：18

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