Transforming the cell surface through proteolysis

被引：33

作者：

Kiessling, LL

Gordon, EJ

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1074-5521(98)90056-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein shedding, or the proteolytic cleavage of a protein from the surface of a cell, is emerging as an important mechanism in the regulation of cellular activity but it is poorly understood. Growing evidence suggesting that protein shedding and protein function are closely linked may lead to new strategies for the treatment of a wide range of diseases.

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收藏

页码：R49 / R62

页数：14

相关论文

共 82 条

[11]

Bemelmans MHA, 1996, CRIT REV IMMUNOL, V16, P1

[12]

BJORNBERG F, 1994, LYMPHOKINE CYTOK RES, V13, P203

[13] A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells [J].

Black, RA ;

Rauch, CT ;

Kozlosky, CJ ;

Peschon, JJ ;

Slack, JL ;

Wolfson, MF ;

Castner, BJ ;

Stocking, KL ;

Reddy, P ;

Srinivasan, S ;

Nelson, N ;

Boiani, N ;

Schooley, KA ;

Gerhart, M ;

Davis, R ;

Fitzner, JN ;

Johnson, RS ;

Paxton, RJ ;

March, CJ ;

Cerretti, DP .

NATURE, 1997, 385 (6618) :729-733

[14] Cleavage of the BMP-4 antagonist chordin by zebrafish tolloid [J].

Blader, P ;

Rastegar, S ;

Fischer, N ;

Strahle, U .

SCIENCE, 1997, 278 (5345) :1937-1940

[15] Metalloprotease-disintegrins: Links to cell adhesion and cleavage of TNF alpha and notch [J].

Blobel, CP .

CELL, 1997, 90 (04) :589-592

[16] FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF THE 2 BETA-1-ADRENOCEPTOR FORMS IN TURKEY ERYTHROCYTES WITH MOLECULAR MASSES OF 50 AND 40 KILODALTONS [J].

BOEGE, F ;

JURSS, R ;

COONEY, D ;

HEKMAN, M ;

KEENAN, AK ;

HELMREICH, EJM .

BIOCHEMISTRY, 1987, 26 (09) :2418-2425

[17] THE ASTACIN FAMILY OF METALLOENDOPEPTIDASES [J].

BOND, JS ;

BEYNON, RJ .

PROTEIN SCIENCE, 1995, 4 (07) :1247-1261

[18]

BOURGET I, 1994, J BIOL CHEM, V269, P6927

[19]

BRAKEBUSCH C, 1994, J BIOL CHEM, V269, P3248

[20] TrkA receptor ectodomain cleavage generates a tyrosine-phosphorylated cell-associated fragment [J].

Cabrera, N ;

DiazRodriguez, E ;

Becker, E ;

MartinZanca, D ;

Pandiella, A .

JOURNAL OF CELL BIOLOGY, 1996, 132 (03) :427-436

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