Reactivities and selectivities in macrocyclic addition reactions with diazoacetates using copper(I) and rhodium(II) catalysts

被引：27

作者：

Doyle, MP ^{[1
]}

Hu, WH ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)01075-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of diazoacetates linked through three ethylene glycol units to allyl, methallyl, propargyl, or furfuryl, catalyzed by copper(I) and rhodium(II) compounds, are investigated for chemoselectivity, diastereoselectivity, and enantioselectivity. The most reactive catalysts show the highest preference for addition over carbon-hydrogen insertion. Addition is favored in the order: prapargyl > furfuyl > methallyl, allyl. (C) 2000 Elsevier Science Ltd. All rights reserved.

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收藏

页码：6265 / 6269

页数：5

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