Timeline - Happy Hollidays: 40th anniversary of the Holliday junction

被引:119
作者
Liu, YL [1 ]
West, SC [1 ]
机构
[1] Canc Res UK, London Res Inst, Clare Hall Labs, S Mimms EN6 3LD, Herts, England
基金
英国工程与自然科学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
D O I
10.1038/nrm1502
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In 1964, the geneticist Robin Holliday proposed a mechanism of DNA-strand exchange that attempted to explain gene-conversion events that occur during meiosis in fungi. His proposal marked the birthday of the now famous cross-stranded DNA structure, or Holliday junction. To understand the importance of the Holliday model we must look back in the history of science beyond the last 40 years, to a time when theories of heredity were being proposed by Gregor Johann Mendel.
引用
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页码:937 / U21
页数:11
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