Recommendations for the categorization of germ cell mutagens

被引：4

作者：

Adler, ID ^{[1
]}

Andrae, U

Kreis, P

Neumann, HG

Thier, R

Wild, D

机构：

[1] CSF, Natl Res Ctr Environm & Hlth, Inst Expt Genet, D-85764 Neuherberg, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Inst Toxicol, D-85764 Neuherberg, Germany

[3] Tech Univ Munich, Inst Toxicol & Environm Hyg, D-80636 Munich, Germany

[4] Univ Wurzburg, Inst Toxicol & Pharmacol, D-97078 Wurzburg, Germany

[5] Univ Dortmund, Inst Occupat Physiol, D-44139 Dortmund, Germany

[6] Fed Ctr Meat Res, Inst Microbiol & Toxicol, D-95326 Kulmbach, Germany

来源：

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 2000年 / 73卷 / 06期

关键词：

germ cell mutagens; list of MAK and BAT values; genetic risk;

D O I：

10.1007/s004200000122

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remain unchanged. Two new categories 3A and 3B are proposed for chemicals suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency that contribute negligibly to human genetic risk provided the MAK value is observed.

引用

页码：428 / 432

页数：5

共 39 条

[1]

Adler I.-D., 1984, MUTAGENICITY TESTING, P275

[2] IN-VIVO CYTOGENETIC EFFECTS OF TRIMETHYLPHOSPHATE AND OF TEPA ON BONE MARROW CELLS OF MALE RATS [J].

ADLER, ID ;

RAMARAO, G ;

EPSTEIN, SS .

MUTATION RESEARCH, 1971, 13 (03) :263-&

[3]

ADLER ID, 1984, BGA SCHRIFTEN, V3, P291

[4]

ADLER ID, 1999, ARBEITSMED SOZIALMED, V34, P400

[5] ANALYSIS OF SISTER CHROMATID EXCHANGE FORMATION INVIVO IN MOUSE SPERMATOGONIA AS A NEW TEST SYSTEM FOR ENVIRONMENTAL MUTAGENS [J].

ALLEN, JW ;

LATT, SA .

NATURE, 1976, 260 (5550) :449-451

[6] Somatic and germ cell effects in rats and mice after treatment with 1,3-butadiene and its metabolites, 1,2-epoxybutene and 1,2,3,4-diepoxybutane [J].

Anderson, D ;

Dobrzynka, MM ;

Jackson, LI ;

Yu, TW ;

Brinkworth, MH .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 1997, 391 (03) :233-242

[7]

AWA AA, 1987, CYTOGENETICS BASIC A, P166

[8] Mouse models of human disease .2. Recent progress and future directions [J].

Bedell, MA ;

Largaespada, DA ;

Jenkins, NA ;

Copeland, NG .

GENES & DEVELOPMENT, 1997, 11 (01) :11-43

[9] ANALYSIS OF X-RAY-INDUCED CHROMOSOMAL TRANSLOCATIONS IN HUMAN AND MARMOSET SPERMATOGONIAL STEM-CELLS [J].

BREWEN, JG ;

PRESTON, RJ ;

GENGOZIAN, N .

NATURE, 1975, 253 (5491) :468-470

[10] MUTATION SURVEILLANCE OF SENTINEL ANOMALIES IN HUNGARY, 1980-1984 [J].

CZEIZEL, A ;

KISVARGA, A .

MUTATION RESEARCH, 1987, 186 (01) :73-79

← 1 2 3 4 →