Recommendations for the categorization of germ cell mutagens

被引：4

作者：

Adler, ID ^{[1
]}

Andrae, U

Kreis, P

Neumann, HG

Thier, R

Wild, D

机构：

[1] CSF, Natl Res Ctr Environm & Hlth, Inst Expt Genet, D-85764 Neuherberg, Germany

[2] GSF, Natl Res Ctr Environm & Hlth, Inst Toxicol, D-85764 Neuherberg, Germany

[3] Tech Univ Munich, Inst Toxicol & Environm Hyg, D-80636 Munich, Germany

[4] Univ Wurzburg, Inst Toxicol & Pharmacol, D-97078 Wurzburg, Germany

[5] Univ Dortmund, Inst Occupat Physiol, D-44139 Dortmund, Germany

[6] Fed Ctr Meat Res, Inst Microbiol & Toxicol, D-95326 Kulmbach, Germany

来源：

INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 2000年 / 73卷 / 06期

关键词：

germ cell mutagens; list of MAK and BAT values; genetic risk;

D O I：

10.1007/s004200000122

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remain unchanged. Two new categories 3A and 3B are proposed for chemicals suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency that contribute negligibly to human genetic risk provided the MAK value is observed.

引用

页码：428 / 432

页数：5

共 39 条

[11]

*DFG, 1999, LIST MAK BAT VAL

[12] DOMINANT LETHAL MUTATIONS IN MALE MICE [J].

EHLING, UH .

ARCHIVES OF TOXICOLOGY, 1977, 38 (1-2) :1-11

[13] INDUCTION OF GENE-MUTATIONS IN MICE - THE MULTIPLE ENDPOINT APPROACH [J].

EHLING, UH ;

CHARLES, DJ ;

FAVOR, J ;

GRAW, J ;

KRATOCHVILOVA, J ;

NEUHAUSERKLAUS, A ;

PRETSCH, W .

MUTATION RESEARCH, 1985, 150 (1-2) :393-401

[14] MAMMALIAN SPOT-TEST (FELLFLECKENTEST) WITH MICE [J].

FAHRIG, R .

ARCHIVES OF TOXICOLOGY, 1977, 38 (1-2) :87-98

[15] RISK-ESTIMATION BASED ON GERM-CELL MUTATIONS IN ANIMALS [J].

FAVOR, J .

GENOME, 1989, 31 (02) :844-852

[16] TRANSGENIC MICE AS MODEL SYSTEMS FOR STUDYING GENE-MUTATIONS INVIVO [J].

GOSSEN, J ;

VIJG, J .

TRENDS IN GENETICS, 1993, 9 (01) :27-31

[17] ANEUPLOIDIES AND MICRONUCLEI IN THE GERM-CELLS OF MALE-MICE OF ADVANCED AGE [J].

LOWE, X ;

COLLINS, B ;

ALLEN, J ;

TITENKOHOLLAND, N ;

BRENEMAN, J ;

VANBEEK, M ;

BISHOP, J ;

WYROBEK, AJ .

MUTATION RESEARCH-DNAGING GENETIC INSTABILITY AND AGING, 1995, 338 (1-6) :59-76

[18] AN INCREASED FREQUENCY OF HUMAN-SPERM CHROMOSOMAL-ABNORMALITIES AFTER RADIOTHERAPY [J].

MARTIN, RH ;

HILDEBRAND, K ;

YAMAMOTO, J ;

RADEMAKER, A ;

BARNES, M ;

DOUGLAS, G ;

ARTHUR, K ;

RINGROSE, T ;

BROWN, IS .

MUTATION RESEARCH, 1986, 174 (03) :219-225

[19] PERSPECTIVES IN MUTATION EPIDEMIOLOGY .6. A 1983 VIEW OF SENTINEL PHENOTYPES [J].

MULVIHILL, JJ ;

CZEIZEL, A .

MUTATION RESEARCH, 1983, 123 (03) :345-361

[20]

NEEL JV, 1974, GENETICS, V76, P311

← 1 2 3 4 →