A convenient procedure for parallel ester hydrolysis

被引：16

作者：

Anderson, MO

Moser, J

Sherrill, J

Guy, RK ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94142 USA

来源：

SYNLETT | 2004年 / 13期

关键词：

ester hydrolysis; deprotection; parallel synthesis; barium hydroxide octahydrate; 9-chloroacridine;

D O I：

10.1055/s-2004-832828

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The treatment of alkyl esters with barium hydroxide octahydrate in methanol followed by protonation with anhydrous hydrogen chloride affords carboxylic acids. The procedure does not require aqueous workup and is particularly suitable for parallel synthesis applications.

引用

页码：2391 / 2393

页数：3