Cationic transfection lipids

被引:72
作者
Liu, DX
Ren, T
Gao, X
机构
[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA
[2] TransTech Pharma Inc, High Point, NC 27265 USA
关键词
cationic lipids; gene delivery; gene therapy; liposomes; nonviral vectors; transfection;
D O I
10.2174/0929867033457386
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.
引用
收藏
页码:1307 / 1315
页数:9
相关论文
共 99 条
[1]  
ANTONIU M, 2001, EXPERT OPIN THER PAT, V11, P1729
[2]   Cationic lipid-mediated transfection in vitro and in vivo [J].
Audouy, S ;
Hoekstra, D .
MOLECULAR MEMBRANE BIOLOGY, 2001, 18 (02) :129-143
[3]   GENE-TRANSFER WITH SYNTHETIC CATIONIC AMPHIPHILES - PROSPECTS FOR GENE-THERAPY [J].
BEHR, JP .
BIOCONJUGATE CHEMISTRY, 1994, 5 (05) :382-389
[4]   EFFICIENT GENE-TRANSFER INTO MAMMALIAN PRIMARY ENDOCRINE-CELLS WITH LIPOPOLYAMINE-COATED DNA [J].
BEHR, JP ;
DEMENEIX, B ;
LOEFFLER, JP ;
MUTUL, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6982-6986
[5]   Physico-chemical characterisation and transfection efficiency of lipid-based gene delivery complexes [J].
Birchall, JC ;
Kellaway, IW ;
Mills, SN .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 183 (02) :195-207
[6]   A VERSATILE VECTOR FOR GENE AND OLIGONUCLEOTIDE TRANSFER INTO CELLS IN CULTURE AND IN-VIVO - POLYETHYLENIMINE [J].
BOUSSIF, O ;
LEZOUALCH, F ;
ZANTA, MA ;
MERGNY, MD ;
SCHERMAN, D ;
DEMENEIX, B ;
BEHR, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7297-7301
[7]   INVIVO TRANSFECTION OF MURINE LUNGS WITH A FUNCTIONING PROKARYOTIC GENE USING A LIPOSOME VEHICLE [J].
BRIGHAM, KL ;
MEYRICK, B ;
CHRISTMAN, B ;
MAGNUSON, M ;
KING, G ;
BERRY, LC .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1989, 298 (04) :278-281
[8]  
CAPLEN NJ, 1995, GENE THER, V2, P603
[9]   Receptor ligand-facilitated gene transfer: Enhancement of liposome-mediated gene transfer and expression by transferrin [J].
Cheng, PW .
HUMAN GENE THERAPY, 1996, 7 (03) :275-282
[10]   Airway delivery of cationic lipid: DNA complexes for cystic fibrosis [J].
Cheng, SH ;
Scheule, RK .
ADVANCED DRUG DELIVERY REVIEWS, 1998, 30 (1-3) :173-184