Cationic transfection lipids

被引：72

作者：

Liu, DX

Ren, T

Gao, X

机构：

[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA

[2] TransTech Pharma Inc, High Point, NC 27265 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 14期

关键词：

cationic lipids; gene delivery; gene therapy; liposomes; nonviral vectors; transfection;

D O I：

10.2174/0929867033457386

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the recent developments in study of cationic lipids as carriers for DNA delivery. Emphasis is placed on a class of compounds as exemplifies by their similarity in structures and transfection activities. The technical aspects are also reviewed on how to prepare DNA-lipid complexes and to perform transfection. A brief discussion of the current views on the mechanism of cationic lipid-mediated DNA transfer is intended to provide new prospects for future developments and further improvement of the current systems.

引用

收藏

页码：1307 / 1315

页数：9

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