Cocaine: Pathophysiology and clinical toxicology

被引:73
作者
Boghdadi, MS [1 ]
Henning, RJ [1 ]
机构
[1] Univ S Florida, Div Cardiol, Tampa, FL 33620 USA
来源
HEART & LUNG | 1997年 / 26卷 / 06期
关键词
D O I
10.1016/S0147-9563(97)90040-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PURPOSE: To review the medical complications of cocaine abuse and the mechanisms of action of cocaine that contribute to medical complications. DATA SOURCES: Pertinent articles identified through a MEDLINE search of the English-language literature from 1985 to 1996 and through a manual search of bibliographies of all identified articles. STUDY SELECTION: AU articles describing complications of cocaine use including case reports, small reported series, and review articles. DATA SYNTHESIS: A qualitative description of reported complications. RESULTS: Since the introduction of freebase and crack, cocaine, multiple medical complications have been observed, and all major body organ systems have been affected. Cocaine can cause acute strokes, myocardial infarction, cardiac dysrhythmias, pulmonary edema, rhabdomyolysis, and acute renal failure. CONCLUSION: Adverse reactions to cocaine should be considered in the differential diagnosis of acute ischemic events thar occur in young adults. General awareness of the significant complications of cocaine will facilitate early diagnosis and prompt treatment.
引用
收藏
页码:466 / 483
页数:18
相关论文
共 200 条
[1]   CRACK-RELATED PERFORATED GASTROPYLORIC ULCER [J].
ABRAMSON, DL ;
GERTLER, JP ;
LEWIS, T ;
KRAL, JG .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1991, 13 (01) :17-19
[2]   ABRUPTIO PLACENTAE ASSOCIATED WITH COCAINE USE [J].
ACKER, D ;
SACHS, BP ;
TRACEY, KJ ;
WISE, WE .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1983, 146 (02) :220-221
[3]   COCAINE INDUCES INTRACELLULAR FREE MG DEFICITS, ISCHEMIA AND STROKE AS OBSERVED BY INVIVO P-31-NMR OF THE BRAIN [J].
ALTURA, BM ;
GUPTA, RK .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1111 (02) :271-274
[4]   COCAINE INDUCES RAPID LOSS OF INTRACELLULAR FREE MG-2+ IN CEREBRAL VASCULAR SMOOTH-MUSCLE CELLS [J].
ALTURA, BM ;
ZHANG, A ;
CHENG, TPO ;
ALTURA, BT .
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1993, 246 (03) :299-301
[5]   COCAINE-ASSOCIATED RHABDOMYOLYSIS AND ACUTE RENAL-FAILURE [J].
ANAND, V ;
SIAMI, G ;
STONE, WJ .
SOUTHERN MEDICAL JOURNAL, 1989, 82 (01) :67-69
[6]   PNEUMOMEDIASTINUM AND CERVICAL EMPHYSEMA FROM THE INHALATION OF FREE BASED COCAINE - REPORT OF 3 CASES [J].
AROESTY, DJ ;
STANLEY, RB ;
CROCKETT, DM .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1986, 94 (03) :372-374
[7]   CORONARY-ARTERY SPASM, CARDIAC-ARREST, TRANSIENT ELECTROCARDIOGRAPHIC Q-WAVES AND STUNNED MYOCARDIUM IN COCAINE-ASSOCIATED ACUTE MYOCARDIAL-INFARCTION [J].
ASCHER, EK ;
STAUFFER, JC ;
GAASCH, WH .
AMERICAN JOURNAL OF CARDIOLOGY, 1988, 61 (11) :939-941
[8]   PULMONARY HISTOPATHOLOGY IN COCAINE ABUSERS [J].
BAILEY, ME ;
FRAIRE, AE ;
GREENBERG, SD ;
BARNARD, J ;
CAGLE, PT .
HUMAN PATHOLOGY, 1994, 25 (02) :203-207
[9]   RUPTURE OF THE ASCENDING AORTA DURING COCAINE INTOXICATION [J].
BARTH, CW ;
BRAY, M ;
ROBERTS, WC .
AMERICAN JOURNAL OF CARDIOLOGY, 1986, 57 (06) :496-496
[10]   ACCELERATED VENTRICULAR RHYTHM AND COCAINE ABUSE [J].
BENCHIMOL, A ;
BARTALL, H ;
DESSER, KB .
ANNALS OF INTERNAL MEDICINE, 1978, 88 (04) :519-520