Cyanopeptolin 963A, a chymotrypsin inhibitor of Microcystis PCC 7806

被引：66

作者：

Bister, B

Keller, S

Baumann, HI

Nicholson, G

Weist, S

Jung, G

Süssmuth, RD

Jüttner, F

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[2] Univ Zurich, Limnol Stn, Inst Plant Biol, CH-8802 Kilchberg, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 10期

关键词：

D O I：

10.1021/np049828f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new depsipeptide, cyanopeptolin 963 A (1), was isolated from an axenic strain of the toxic freshwater cyanobacterium Microcystis PCC 7806. The structure of this compound was elucidated by chemical and spectroscopic analyses, including high-resolution ESI-FTICR-MS, 2-D NMR, and GC-MS of the hydrolysate. The major structural difference compared to previously characterized cyanopeptolins of this strain is the replacement of the basic amino acid in position 3 by L-tyrosine. Compound 1 displayed inhibitory activity against chymotrypsin with an IC50 value of 0.9 muM.

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页码：1755 / 1757

页数：3

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