In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months

被引：54

作者：

Di Mascio, M

Dornadula, G

Zhang, H

Sullivan, J

Xu, Y

Kulkosky, J

Pomerantz, RJ

Perelson, AS

机构：

[1] Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Div Theoret, Los Alamos, NM 87545 USA

[2] Thomas Jefferson Univ, Dorrance H Hamilton Labs, Ctr Human Virol, Philadelphia, PA 19107 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 03期

关键词：

D O I：

10.1128/JVI.77.3.2271-2275.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Three of five virally suppressed human immunodeficiency virus type I (HIV-1) -infected patients treated with highly active antiretroviral therapy and followed intensively with a supersensitive reverse transcriptase PCR assay with a lower limit of quantitation of 5 copies/ml showed statistically significant viral load decays below 50 copies/ml, with half-lives of 5 to 8 months and a mean of 6 months. This range of half-lives is consistent with the estimated half-life of the latent HIV-1 reservoir in the peripheral blood. Those patients without decay of viral load in plasma may have significant cryptic HIV-1 residual replication.

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收藏

页码：2271 / 2275

页数：5

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