Sleep Induced by Stimulation in the Human Pedunculopontine Nucleus Area

被引：74

作者：

Arnulf, Isabelle ^{[1
]}

Ferraye, Muriel ^{[2
,3
]}

Fraix, Valerie ^{[2
,3
]}

Benabid, Alim Louis ^{[2
,3
,4
]}

Chabardes, Stephan ^{[2
,3
,4
]}

Goetz, Laurent ^{[2
,3
]}

Pollak, Pierre ^{[2
,3
,4
]}

Debu, Bettina ^{[2
,3
]}

机构：

[1] Univ Paris 06, Pitie Salpetriere Hosp, Assistance Publ Hop Paris, INSERM,Sleep Disorders Unit,UMR 975, Paris, France

[2] Grenoble Univ, Grenoble, France

[3] INSERM, U836, Grenoble Inst Neurosci, Grenoble, France

[4] Univ Hosp Grenoble, Grenoble, France

来源：

ANNALS OF NEUROLOGY | 2010年 / 67卷 / 04期

关键词：

DEEP BRAIN-STIMULATION; PARKINSONS-DISEASE; REM-SLEEP; HUMAN PONS; LOCALIZATION; PROJECTIONS; ATLAS;

D O I：

10.1002/ana.21912

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The pedunculopontine nucleus is part of the reticular ascending arousal system and is involved in locomotion and sleep. Two patients with Parkinson disease received electrodes that stimulated the pedunculopontine nucleus area to alleviate their severe gait impairment. Instead, we found that low-frequency stimulation of the pedunculopontine nucleus area increased alertness, whereas high-frequency stimulation induced non-rapid eye movement sleep. In addition, the sudden withdrawal of the low-frequency stimulation was consistently followed by rapid eye movement sleep episodes in 1 patient. These data have the potential to benefit patients who suffer from sleep disorders. ANN NEUROL 2010;67:546-549

引用

收藏

页码：546 / 549

页数：4

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