Spiral breakup as a model of ventricular fibrillation

被引:170
作者
Panfilov, AV [1 ]
机构
[1] Univ Utrecht, Dept Theoret Biol, NL-3584 CH Utrecht, Netherlands
关键词
D O I
10.1063/1.166287
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
The phenomenon of spiral breakup in a 2D and a 3D excitable medium is described. Differences between breakup in two dimensions and in three dimensions are discussed. Spiral breakup in an anatomical model of the ventricles of the heart is also studied. The patterns of excitation in the heart are presented at different wavelengths together with their electrocardiograms. Finally it is suggested that the phenomenon of spiral breakup is a possible mechanism of the ventricular fibrillation (VF). (C) 1998 American Institute of Physics.
引用
收藏
页码:57 / 64
页数:8
相关论文
共 34 条
[1]  
Abildskov J. A., 1991, J CARDIOVASC ELECTR, V2, P224, DOI [10.1111/j.1540-8167.1991.tb01321.x, DOI 10.1111/J.1540-8167.1991.TB01321.X]
[2]  
BAR M, 1993, PHYS REV E, V48, pR1635
[3]   RECONSTRUCTION OF ACTION POTENTIAL OF VENTRICULAR MYOCARDIAL FIBERS [J].
BEELER, GW ;
REUTER, H .
JOURNAL OF PHYSIOLOGY-LONDON, 1977, 268 (01) :177-210
[4]   INSTABILITIES OF A PROPAGATING PULSE IN A RING OF EXCITABLE MEDIA [J].
COURTEMANCHE, M ;
GLASS, L ;
KEENER, JP .
PHYSICAL REVIEW LETTERS, 1993, 70 (14) :2182-2185
[5]   RE-ENTRANT ROTATING WAVES IN A BEELER-REUTER BASED MODEL OF TWO-DIMENSIONAL CARDIAC ELECTRICAL ACTIVITY [J].
Courtemanche, Marc ;
Winfree, Arthur T. .
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 1991, 1 (02) :431-444
[6]   STATIONARY AND DRIFTING SPIRAL WAVES OF EXCITATION IN ISOLATED CARDIAC-MUSCLE [J].
DAVIDENKO, JM ;
PERTSOV, AV ;
SALOMONSZ, R ;
BAXTER, W ;
JALIFE, J .
NATURE, 1992, 355 (6358) :349-351
[7]  
ELHARRAR V, 1983, AM J PHYSIOL, V244, pH782, DOI 10.1152/ajpheart.1983.244.6.H782
[8]   A CELLULAR AUTOMATON MODEL OF EXCITABLE MEDIA INCLUDING CURVATURE AND DISPERSION [J].
GERHARDT, M ;
SCHUSTER, H ;
TYSON, JJ .
SCIENCE, 1990, 247 (4950) :1563-1566
[9]   SOME OBSERVATIONS ON THE QUESTION - IS VENTRICULAR-FIBRILLATION CHAOS [J].
GOLDBERGER, AL ;
BHARGAVA, V ;
WEST, BJ ;
MANDELL, AJ .
PHYSICA D, 1986, 19 (02) :282-289
[10]  
Gray R., COMMUNICATION