Rapid, efficient synthesis of heterobifunctional biodegradable dendrimers

被引：110

作者：

Goodwin, Andrew P. ^{[1
]}

Lam, Stephanie S. ^{[1
]}

Frechet, Jean M. J. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 22期

关键词：

D O I：

10.1021/ja071530z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the preparation of heterobifunctional biodegradable dendrimers is described involving the preparation of a symmetric aliphatic ester dendrimer derived from 2,2-bis(hydroxymethyl)propanoic acid bearing a cyclic carbonate periphery, followed by opening of the carbonate moieties with a functional amine. This approach requiring no chromatographic purification steps was demonstrated with the preparation of a dendrimer bearing eight protected aldehydes and eight alkynes at its periphery.

引用

页码：6994 / +

页数：3

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