Transcriptional regulation of B-cell differentiation

被引：59

作者：

Reya, T ^{[1
]}

Grosschedl, R ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(98)80244-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription factors influence B cell differentiation by regulating the expression of numerous lineage-specific genes. Recent studies have identified factors that regulate differentiation of hematopoietic stem cells into B cell progenitors (PU.1 and Ikaros), and further differentiation of these progenitors into mature B cells (NF kappa B, E2A, early B cell factor [EBF] and B cell specific activator protein [BSAP]). In addition, these studies demonstrate that complex interactions and redundancies among transcription factors safeguard the precise patterns of gene expression required for normal B cell differentiation. (C) Current Biology Ltd ISSN 0952-7915.

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收藏

页码：158 / 165

页数：8

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