Development and functional specialization of CD103+dendritic cells

被引：214

作者：

del Rio, Maria-Luisa ^{[1
]}

Bernhardt, Guenter ^{[1
]}

Rodriguez-Barbosa, Jose-Ignacio ^{[2
]}

Foerster, Reinhold ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Immunol, D-30625 Hannover, Germany

[2] Univ Leon, Inst Biomed, E-24071 Leon, Spain

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 234卷

关键词：

CD103; dendritic cell; lung; intestine; antigen presentation; REGULATORY T-CELLS; CD8-ALPHA(+) DENDRITIC CELLS; PERIPHERAL LYMPHOID ORGANS; BLOOD MONOCYTE SUBSETS; MHC CLASS-I; CROSS-PRESENTATION; STEADY-STATE; BONE-MARROW; SELF-ANTIGENS; LANGERHANS CELLS;

D O I：

10.1111/j.0105-2896.2009.00874.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103+ DCs display distinct functional activities. Migratory CD103+ DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8+ T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103+ DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103+ DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3+ regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103+ DCs as important regulators of the immune response.

引用

页码：268 / 281

页数：14

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