Evidence for biotype-specific effects of bovine viral diarrhoea virus on biological responses in acutely infected calves

被引：23

作者：

Lambot, M ^{[1
]}

Joris, E ^{[1
]}

Douart, A ^{[1
]}

Lyaku, J ^{[1
]}

Letesson, JJ ^{[1
]}

Pastoret, PP ^{[1
]}

机构：

[1] Univ Liege, Fac Vet Med, Dept Immunol Vaccinol, B-4000 Liege, Belgium

来源：

JOURNAL OF GENERAL VIROLOGY | 1998年 / 79卷

关键词：

D O I：

10.1099/0022-1317-79-1-27

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The relationship between the two biotypes of bovine viral diarrhoea virus (BVDV) and the biological responses they induce was studied in 3- to 6-month-old calves inoculated intranasally with a homologous pair of non-cytopathic and cytopathic strains. Marked differences in virological and serological events occurred following exposure to a specific BVDV strain. The non-cytopathic biotype was frequently recovered from nasal secretions and blood cells during the first 28 days post-inoculation whereas the cytopathic counterpart was detected infrequently in nasopharyngeal swabs only. There was no correlation of the recovery of infectious virus in vivo with the biotype-specific neutralizing humoral immune response. Furthermore, seroconversion did not correlate with resistance to reinfection as judged by the transient viraemia and/or shedding of virus observed in a challenge experiment.

引用

页码：27 / 30

页数：4

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