Endotoxin and NO induce MIP-1γ gene transcription in ANA-1 murine macrophages

被引：3

作者：

Guo, HT ^{[1
]}

Cai, CQ ^{[1
]}

Kuo, PC ^{[1
]}

机构：

[1] Georgetown Univ Hosp, Dept Surg, Washington, DC 20007 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 277卷 / 03期

关键词：

D O I：

10.1006/bbrc.2000.3718

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The host response to gram-negative endotoxin is characterized by an influx of inflammatory cells into host tissues, mediated in part by localized production of chemokines. In this study, using subtractive suppression hybridization analysis, we demonstrate that ANA-1 murine macrophages produce the CC chemokine, MIP-1 gamma, in response to LPS-mediated NO production. Gene transcription and protein translation are upregulated in the setting of LPS-induced NO synthesis. However, NO alone is a necessary but insufficient cofactor for induction of MIP-1 gamma protein expression; an NO-independent LPS signalling pathway is also required. This study suggests a novel mechanism by which NO modulates the host inflammatory response to endotoxin, (C) 2000 Academic Press.

引用

页码：617 / 621

页数：5