Mads and Smads in TGFβ signalling

被引：178

作者：

Attisano, L

Wrana, JL

机构：

[1] Hosp Sick Children, Program Dev Biol, Toronto, ON M5X 1X8, Canada

[2] Univ Toronto, Dept Anat & Cell Biol, Toronto, ON M5S 1X8, Canada

[3] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5X 1X8, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0955-0674(98)80141-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases. (C) Current Biology Ltd ISSN 0955-0674.

引用

页码：188 / 194

页数：7

共 65 条

[41] Newfeld SJ, 1997, DEVELOPMENT, V124, P3167
[42] The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway
Patterson, GI
Koweek, A
Wong, A
Liu, YX
Ruvkun, G
[J]. GENES & DEVELOPMENT, 1997, 11 (20) : 2679 - 2690
[43] RAFTERY LA, 1995, GENETICS, V139, P241
[44] Mad-related genes in the human
Riggins, GJ
Thiagalingam, S
Rozenblum, E
Weinstein, CL
Kern, SE
Hamilton, SR
Willson, JKV
Markowitz, SD
Kinzler, KW
Vogelstein, B
[J]. NATURE GENETICS, 1996, 13 (03) : 347 - 349
[45] Riggins GJ, 1997, CANCER RES, V57, P2578
[46] Rotin D, 1998, CURR TOP MICROBIOL, V228, P115
[47] MAD about colorectal cancer
Rustgi, AK
[J]. GASTROENTEROLOGY, 1996, 111 (05) : 1387 - 1389
[48] Caenorhabditis elegans genes sma2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components
Savage, C
Das, P
Finelli, AL
Townsend, SR
Sun, CY
Baird, SE
Padgett, RW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) : 790 - 794
[49] SEKELSKY JJ, 1995, GENETICS, V139, P1347
[50] A structural basis for mutational inactivation of the tumour suppressor Smad4
Shi, YG
Hata, A
Lo, RS
Massague, J
Pavletich, NP
[J]. NATURE, 1997, 388 (6637) : 87 - 93

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