Netrin signaling leading to directed growth cone steering

被引：113

作者：

Round, Jennifer ^{[1
]}

Stein, Elke ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol & Cell Biol, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.conb.2007.01.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the developing nervous system, nerve cells and axons respond to various attractive and repulsive guidance cues while traveling to their final destination. Netrins are bifunctional guidance cues that attract several classes of axons but repel others. The response of an axon to netrins is dictated by the composition of netrin receptors on the cell surface and the internal state of the growth cone. Recent analyses have identified several signal transduction pathways that contribute to netrin-mediated guidance. A model emerges in which tyrosine phosphorylation, phosphaticlylinositol signaling and regulation by Rho GTPases act in concert to trigger extension of axons and turning of growth cones in response to Netrin1.

引用

页码：15 / 21

页数：7

共 51 条

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