Potentiated antitumour effects of cisplatin and lovastatin against MmB16 melanoma in mice

被引：87

作者：

Feleszko, W ^{[1
]}

Zagozdzon, R ^{[1
]}

Golab, J ^{[1
]}

Jakobisiak, M ^{[1
]}

机构：

[1] Sch Med, Inst Biostruct, Dept Immunol, PL-02004 Warsaw, Poland

来源：

EUROPEAN JOURNAL OF CANCER | 1998年 / 34卷 / 03期

关键词：

lovastatin; cisplatin; melanoma; tumour therapy;

D O I：

10.1016/S0959-8049(97)10034-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lovastatin, the drug used in the treatment of hypercholesterolaemia, has previously been reported to exert synergistic antitumour activity in a melanoma model in mice when used together with some immune response modifiers. In this study, we examined the antitumour effect of cisplatin augmented by its combined application with lovastatin, both in vitro and in vivo, in a murine melanoma model. The results of this study suggest that lovastatin may enhance the therapeutic effects of cisplatin in the treatment of malignant melanomas. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：406 / 411

页数：6

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