Dock-family exchange factors in cell migration and disease

被引：160

作者：

Gadea, Gilles ^{[1
,2
]}

Blangy, Anne ^{[1
,2
]}

机构：

[1] CNRS UMR 5237, Ctr Rech Biochim Macromol, F-34293 Montpellier 5, France

[2] Univ Montpellier, Montpellier, France

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2014年 / 93卷 / 10-12期

关键词：

Dock180; Dock1; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Dock10; Dock11; Zizimin; DHR2; Rac1; Cdc42; Adhesion; Migration; Cancer; Exchange factor; Rho GTPase; Osteoclast; Amoeboid; GPCR; Integrin; Synapse; EPITHELIAL-MESENCHYMAL TRANSITION; NUCLEOTIDE EXCHANGE; RAC ACTIVATION; CDC42; ACTIVATOR; RHO-FAMILY; RECEPTOR; AXONAL OUTGROWTH; GENE-EXPRESSION; T-LYMPHOCYTE; PROTEIN;

D O I：

10.1016/j.ejcb.2014.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：466 / 477

页数：12

共 134 条

[1] DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population [J].

Alkelai, Anna ;

Lupoli, Sara ;

Greenbaum, Lior ;

Kohn, Yoav ;

Kanyas-Sarner, Kyra ;

Ben-Asher, Edna ;

Lancet, Doron ;

Macciardi, Fabio ;

Lerer, Bernard .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2012, 15 (04) :459-469

[2] Improved gene expression signature of testicular carcinoma in situ [J].

Almstrup, Kristian ;

Leffers, Henrik ;

Lothe, Ragnhild A. ;

Skakkebek, Niels E. ;

Sonne, Si B. ;

Nielsen, John E. ;

Meyts, Ewa Rajpert-De ;

Skotheim, Rolf I. .

INTERNATIONAL JOURNAL OF ANDROLOGY, 2007, 30 (04) :292-302

[3] Clinical, Immunological and Molecular Characterization of DOCK8 and DOCK8-like Deficient Patients: Single Center Experience of Twenty Five Patients [J].

Alsum, Zobaida ;

Hawwari, Abbas ;

Alsmadi, Osama ;

Al-Hissi, Safa ;

Borrero, Esteban ;

Abu-staiteh, Asma' ;

Khalak, Hanif G. ;

Wakil, Salma ;

Eldali, Abdelmoneim M. ;

Arnaout, Rand ;

Al-ghonaium, Abdulaziz ;

Al-Muhsen, Saleh ;

Al-Dhekri, Hasan ;

Al-Saud, Bandar ;

Al-Mousa, Hamoud .

JOURNAL OF CLINICAL IMMUNOLOGY, 2013, 33 (01) :55-67

[4] p130Cas: A key signalling node in health and disease [J].

Barrett, Angela ;

Pellet-Many, Caroline ;

Zachary, Ian C. ;

Evans, Ian M. ;

Frankel, Paul .

CELLULAR SIGNALLING, 2013, 25 (04) :766-777

[5] A novel role of Rac1 GTPase in JCV T-antigen-mediated β-catenin stabilization [J].

Bhattacharyya, R. ;

Noch, E. K. ;

Khalili, K. .

ONCOGENE, 2007, 26 (55) :7628-7636

[6] Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function [J].

Blasius, Amanda L. ;

Brandl, Katharina ;

Crozat, Karine ;

Xia, Yu ;

Khovananth, Kevin ;

Krebs, Philippe ;

Smart, Nora G. ;

Zampolli, Antonella ;

Ruggeri, Zaverio M. ;

Beutler, Bruce A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (08) :2706-2711

[7] Evolution of the Rho family of Ras-like GTPases in eukaryotes [J].

Boureux, Anthony ;

Vignal, Emmanuel ;

Faure, Sandrine ;

Fort, Philippe .

MOLECULAR BIOLOGY AND EVOLUTION, 2007, 24 (01) :203-216

[8] Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: Identification of essential genes in osteoclasts [J].

Brazier, Helene ;

Stephens, Sebastien ;

Ory, Stephane ;

Fort, Philippe ;

Morrison, Nigel ;

Blangy, Anne .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (09) :1387-1398

[9] Identification of novel Smad2 and Smad3 associated proteins in response to TGF-β1 [J].

Brown, Kimberly A. ;

Ham, Amy-Joan L. ;

Clark, Cara N. ;

Meller, Nahum ;

Law, Brian K. ;

Chytil, Anna ;

Cheng, Nikki ;

Pietenpol, Jennifer A. ;

Moses, Harold L. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2008, 105 (02) :596-611

[10] Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex [J].

Brugnera, E ;

Haney, L ;

Grimsley, C ;

Lu, MJ ;

Walk, SF ;

Tosello-Trampont, AC ;

Macara, IG ;

Madhani, H ;

Fink, GR ;

Ravichandran, KS .

NATURE CELL BIOLOGY, 2002, 4 (08) :574-582

← 1 2 3 4 5 6 7 8 9 10 →