Dock-family exchange factors in cell migration and disease

被引：160

作者：

Gadea, Gilles ^{[1
,2
]}

Blangy, Anne ^{[1
,2
]}

机构：

[1] CNRS UMR 5237, Ctr Rech Biochim Macromol, F-34293 Montpellier 5, France

[2] Univ Montpellier, Montpellier, France

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2014年 / 93卷 / 10-12期

关键词：

Dock180; Dock1; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Dock10; Dock11; Zizimin; DHR2; Rac1; Cdc42; Adhesion; Migration; Cancer; Exchange factor; Rho GTPase; Osteoclast; Amoeboid; GPCR; Integrin; Synapse; EPITHELIAL-MESENCHYMAL TRANSITION; NUCLEOTIDE EXCHANGE; RAC ACTIVATION; CDC42; ACTIVATOR; RHO-FAMILY; RECEPTOR; AXONAL OUTGROWTH; GENE-EXPRESSION; T-LYMPHOCYTE; PROTEIN;

D O I：

10.1016/j.ejcb.2014.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：466 / 477

页数：12

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