Circadian and circannual rhythms in the function of central 5-HT1A receptors in laboratory rats

被引：21

作者：

Nagayama, H ^{[1
]}

Lu, JQ ^{[1
]}

机构：

[1] Oita Med Univ, Dept Neuropsychiat, Oita 87955, Japan

来源：

PSYCHOPHARMACOLOGY | 1998年 / 135卷 / 03期

关键词：

circannual rhythm; circadian rhythm; serotonin(1A) receptor; 8-OH-DPAT; chronopharmacology;

D O I：

10.1007/s002130050510

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to elucidate whether a circannual rhythm exists in the function of the central serotonin (5-HT) system, we examined the responsiveness of rats to a selective 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), at different hours of the day in different seasons. The results indicate that both a circadian rhythm and a circannual rhythm exist in the responsiveness. The phases of the circadian rhythm exhibit 1-year period variations, while those of the circannual rhythm exhibit 1-day period variations. These results will help to clarify the disparities among the reports on circadian and circannual rhythms in the phenomenon related to the central 5-HT system.

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收藏

页码：279 / 283

页数：5

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