T-cell responses of vaccinated cancer patients

被引：73

作者：

Coulie, PG ^{[1
]}

van der Bruggen, P ^{[1
]}

机构：

[1] Univ Louvain, Cellular Genet Unit, Christian Duve Inst Cellular Pathol, B-1200 Brussels, Belgium

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(03)00009-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Following vaccination with defined tumor antigens that are recognized by T cells, a small proportion of cancer patients display tumor regressions. Several reports describe anti-vaccine T-cell responses, evaluated with a variety of methods, for example, by assessing T-cell function or expression of specific TCR. However, a correlation between these T-cell responses and the tumor regressions has not yet been established. It appears that some patients display tumor regression with an unexpectedly low frequency of anti-vaccine T cells.

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页码：131 / 137

页数：7

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