New class of steroidal alkaloids from Fritillaria imperialis

被引：33

作者：

Akhtar, MN

Atta-ur-Rahman, A

Choudhary, MI ^{[1
]}

Sener, B

Erdogan, I

Tsuda, Y

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

来源：

PHYTOCHEMISTRY | 2003年 / 63卷 / 01期

关键词：

Fritillaria imperialis; impranine; dihydroimpranine; fetisinine; impranane-type steroidal alkaloids;

D O I：

10.1016/S0031-9422(02)00569-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Two members of a new class of C-nor-D-homo steroidal alkaloids, impranine (1) and dihydroimpranine (2) along with a new pyridyl-pregnane-type steroidal alkaloid, fetisinine (3) and a known base, korsevine (4) were isolated from the bulbs of Fritillaria imperialis. The structures of the compounds were established on the basis of spectroscopic techniques and some chemical transformations. Compounds I and 2 form a new class of steroidal alkaloids, named as "impranane." (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：115 / 122

页数：8

共 27 条

[1]

New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities [J].