Drugs of the 21st century: telithromycin (HMR 3647) - the first ketolide

被引：92

作者：

Ackermann, G ^{[1
]}

Rodloff, AC ^{[1
]}

机构：

[1] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, D-04103 Leipzig, Germany

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 03期

关键词：

new antimicrobials; telithromycin; resistance;

D O I：

10.1093/jac/dkg123

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Telithromycin (HMR 3647) is the first ketolide introduced into clinical practice. Ketolides are semisynthetic derivates of erythromycin A that carry novel biological properties on the erythronolide A ring. This new class of antimicrobials was designed to overcome current resistance mechanisms against erythromycin A within Gram-positive cocci. Ketolides do not induce macrolide-lincosamide-streptogramin B (MLSB) resistance and are active against erythromycin resistance methylase gene (erm)-carrying Gram-positive cocci. This review summarizes published data on telithromycin and intends to define the challenge that a new antimicrobial brings to medical practice.

引用

页码：497 / 511

页数：15

共 104 条

[21] BRYSKIER A, 2002, MIL DRUG TH, P97
[22] BUCHANAN P, 2001, 41 INT C ANT AG CHEM, P461
[23] Antimicrobial resistance amongst isolates of Streptococcus pyogenes and Staphylococcus aureus in the PROTEKT antimicrobial surveillance programme during 1999-2000
Cantón, R
Loza, E
Morosini, MI
Baquero, F
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 50 : 9 - 24
[24] CARBON C, 2000, 40 INT C ANT AG CHEM, P490
[25] Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics
Champney, WS
Tober, CL
[J]. CURRENT MICROBIOLOGY, 1998, 37 (06) : 418 - 425
[26] Champney WS, 2001, CURR MICROBIOL, V42, P203
[27] Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes
Clancy, J
Petitpas, J
DibHajj, F
Yuan, W
Cronan, M
Kamath, AV
Bergeron, J
Retsema, JA
[J]. MOLECULAR MICROBIOLOGY, 1996, 22 (05) : 867 - 879
[28] Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice
Consigny, S
Bentoucha, A
Bonnafous, P
Grosset, J
Ji, BH
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (10) : 2919 - 2921
[29] CRAIG WA, 2001, 41 INT C ANT AG CHEM, P34
[30] CUNDLIFFE E, 1990, RIBOSOME, P479

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