Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides:: Novel and selective histamine H3 receptor antagonists

被引：46

作者：

Faghih, R ^{[1
]}

Dwight, W ^{[1
]}

Pan, JB ^{[1
]}

Fox, GB ^{[1
]}

Krueger, KM ^{[1
]}

Esbenshade, TA ^{[1
]}

McVey, JM ^{[1
]}

Marsh, K ^{[1
]}

Bennani, YL ^{[1
]}

Hancock, AA ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Neurosci Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(03)00118-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 4'-[(NRIR2-1-yl)]-propoxy-biaryl-4-carboxamides were designed and synthesized. All compounds were tested for affinity at histamine H(3)receptors. Most compounds were highly potent and selective for human and rat H-3 receptors and selected examples such as A-349821 showed functional antagonism of H3 receptors in vitro and in a mouse dipsogenia model. (C) 2003 Published by Elsevier Science Ltd.

引用

页码：1325 / 1328

页数：4

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