Epidermal stem cell diversity and quiescence

被引：149

作者：

Watt, Fiona M. ^{[1
,2
]}

Jensen, Kim B. ^{[1
]}

机构：

[1] Wellcome Trust Ctr Stem Cell Res, Cambridge, England

[2] Li Ka Shing Ctr, CRUK Cambridge Res Inst, Cambridge, England

来源：

EMBO MOLECULAR MEDICINE | 2009年 / 1卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

NFATc1; Myc; EGF receptor; beta-catenin; Lrig1; GROWTH-FACTOR RECEPTOR; HAIR FOLLICLE BULGE; TRANSIT-AMPLIFYING CELLS; LABEL-RETAINING CELLS; ADULT-MOUSE SKIN; BETA-CATENIN; EGF RECEPTOR; C-MYC; MAMMALIAN EPIDERMIS; KERATINOCYTE GROWTH;

D O I：

10.1002/emmm.200900033

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.

引用

页码：260 / 267

页数：8

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