Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress

被引：54

作者：

Chlench, Sven

Disassa, Nigussie Mecha

Hohberg, Margret

Hoffmann, Christian

Pohlkamp, Theresa

Beyer, Gabriele

Bongrazio, Mauro

Da Silva-Azevedo, Luis

Baum, Oliver

Radlach Pries, Axel

Zakrzewicz, Andreas

机构：

[1] Charite, Inst Physiol, D-14195 Berlin, Germany

[2] Invitek GmbH, D-13125 Berlin, Germany

[3] Univ Bern, Inst Anat, CH-3009 Bern 12, Switzerland

来源：

FEBS LETTERS | 2007年 / 581卷 / 04期

关键词：

angiogenesis; shear stress; endothelium; Foxo-1; Ang-2; Tie2;

D O I：

10.1016/j.febslet.2007.01.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1 -dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm(2), 24 h), nuclear exclusion of Foxo-I by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：673 / 680

页数：8

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