DNA manipulation, sorting, and mapping in nanofluidic systems

被引：157

作者：

Levy, Stephen L. ^{[1
]}

Craighead, Harold G. ^{[1
]}

机构：

[1] Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY 14853 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 03期

关键词：

SINGLE-MOLECULE DETECTION; FREE SOLUTION MOBILITY; LONG DNA; CONFINED POLYMERS; ENTROPIC TRAP; STRANDED-DNA; SEPARATION; DYNAMICS; FABRICATION; ELECTROPHORESIS;

D O I：

10.1039/b820266b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).

引用

页码：1133 / 1152

页数：20

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