Optimization of glycosylation reactions in a microreactor

被引：46

作者：

Geyer, Karolin ^{[1
]}

Seeberger, Peter H. ^{[1
]}

机构：

[1] ETH, Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2007年 / 90卷 / 02期

关键词：

D O I：

10.1002/hlca.200790046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Glycosylations are notoriously difficult reactions that require extensive optimization regarding the type of anomeric leaving group, solvent, reaction temperature, and reaction time. Described is the use of a silicon-based microreactor to screen reaction conditions and to scale-up synthetic procedures. For the first time, glycosyl phosphates were employed in a microreactor. The optimized reaction conditions were successfully transferred to a batch process.

引用

页码：395 / 403

页数：9

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