The antifungal activity of twenty-four southern African Combretum species (Combretaceae)

被引:114
作者
Masoko, P. [1 ]
Picard, J. [1 ]
Eloff, J. N. [1 ]
机构
[1] Univ Pretoria, Fac Vet Sci, Dept Vet Trop Dis, ZA-0110 Onderstepoort, South Africa
基金
新加坡国家研究基金会;
关键词
Combretaceae; Combretum species; antifungal activity; MIC; ANTIBACTERIAL COMPOUNDS; PLANT-EXTRACTS; TERMINALIA;
D O I
10.1016/j.sajb.2006.09.010
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The antifungal activities of acetone, hexane, dichloromethane and methanol leaf extracts of 24 South African Combretum species were determined against five fungal animal pathogens (Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Microsporum canis and Sporothrix schenckii) representing yeasts, moulds and dimorphic fungi. MIC's determined after 48 It were usually two times higher than values determined after 24 It. Most of the antifungal extracts had MIC values of c. 0.08 mg/ml, some with MIC values as low as 0.02 mg/ml. These are substantially better values that reported in the literature to date. M. canis was the most susceptible microorganism followed by S. schenckii. A. fumigatus was the most resistant of the pathogens tested. Methanol extracted the highest quantity from leaves, but the acetone extracts had the highest antifungal activity in practically all cases. The methanolic extracts of C. moggii and C. petrophilum were however most active against all the pathogens. All extracts of C. nelsonii were also very effective against all the pathogens. Based on these results and work done earlier, C. nelsonii was selected for fractionation and bioassay-guided isolation of the antifungal compounds followed by C. albopuntactum, and C. imberbe. (c) 2007 SAAB. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:173 / 183
页数:11
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