Improved protein-adsorption resistance of polyethersulfone membranes via surface segregation of ultrahigh molecular weight poly(styrene-alt-maleic anhydride)

被引：53

作者：

Zhu, Li-Ping ^{[1
]}

Zhang, Xin-Xin ^{[1
]}

Xu, Li ^{[1
]}

Du, Chun-Hui ^{[1
]}

Zhu, Bao-Ku ^{[1
]}

Xu, You-Yi ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Polymer Sci, Hangzhou 310027, Yuquan, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2007年 / 57卷 / 02期

基金：

中国国家自然科学基金;

关键词：

polyethersulfone; styrene-maleic anhydride alternating copolymer; membrane; surface segregation; protein-adsorption resistance;

D O I：

10.1016/j.colsurfb.2007.01.021

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A styrene-maleic anhydride (SMA) alternating copolymer with ultrahigh molecular weight (M-w > 10(6)) synthesized in super critical carbon dioxide (SC CO2) medium was used as hydrophilic polymeric additive in the preparation of polyethersulfone (PES) membranes. The PES/SMA blend membranes were prepared by immersion precipitation process. X-ray photoelectronic spectroscopy (XPS) measurements confirmed that the hydrolyzed SMA preferentially segregated to membrane-coagulant interface during membrane formation. For the PES/SMA blend membranes, no big change was observed in the cross-sectional structure and the mechanical properties were well maintained after SMA addition except that a thicker top layer was formed. The surface morphology analysis by atomic force microscopy (AFM) showed that the membrane surface roughness increased with the added SMA amount. The results of water contact angle, water absorbance measurements and static protein adsorption experiments revealed that the surface enrichment of SMA endowed PES/SMA blend membranes with significantly improved surface hydrophilicity and protein-adsorption resistance. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：189 / 197

页数：9

共 34 条

[1] Polymer blends of polyamide-6 (PA6) and poly(phenylene oxide) (PPO) compatibilized by styrene-maleic anhydride (SMA) copolymer [J].

Chiang, CR ;

Chang, FC .

POLYMER, 1997, 38 (19) :4807-4817

[2] COMPATIBILIZED POLYMER BLENDS OF ISOTACTIC POLYPROPYLENE AND STYRENE-MALEIC ANHYDRIDE COPOLYMER [J].

DHARMARAJAN, N ;

DATTA, S ;

STRATE, GV ;

BAN, L .

POLYMER, 1995, 36 (20) :3849-3861

[3] Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery [J].

Gan, Q ;

Wang, T ;

Cochrane, C ;

McCarron, P .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2005, 44 (2-3) :65-73

[4] Nanometer-scale roughness having little effect on the amount or structure of adsorbed protein [J].

Han, M ;

Sethuraman, A ;

Kane, RS ;

Belfort, G .

LANGMUIR, 2003, 19 (23) :9868-9872

[5] Thermodynamic and rheological variation in polysulfone solution by PVP and its effect in the preparation of phase inversion membrane [J].

Han, MJ ;

Nam, ST .

JOURNAL OF MEMBRANE SCIENCE, 2002, 202 (1-2) :55-61

[6] Preparation of blood-compatible hollow fibers from a polymer alloy composed of polysulfone and 2-methacryloyloxyethyl phosphorylcholine polymer [J].

Hasegawa, T ;

Iwasaki, Y ;

Ishihara, K .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 63 (03) :333-341

[7] Preparation and performance of protein-adsorption-resistant asymmetric porous membrane composed of polysulfone/phospholipid polymer blend [J].

Hasegawa, T ;

Iwasaki, Y ;

Ishihara, K .

BIOMATERIALS, 2001, 22 (03) :243-251

[8] ATRP of amphiphilic graft copolymers based on PVDF and their use as membrane additives [J].

Hester, JF ;

Banerjee, P ;

Won, YY ;

Akthakul, A ;

Acar, MH ;

Mayes, AM .

MACROMOLECULES, 2002, 35 (20) :7652-7661

[9] Design and performance of foul-resistant poly(vinylidene fluoride) membranes prepared in a single-step by surface segregation [J].

Hester, JF ;

Mayes, AM .

JOURNAL OF MEMBRANE SCIENCE, 2002, 202 (1-2) :119-135

[10] Preparation of protein-resistant surfaces on poly(vinylidene fluoride) membranes via surface segregation [J].

Hester, JF ;

Banerjee, P ;

Mayes, AM .

MACROMOLECULES, 1999, 32 (05) :1643-1650

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