Studies on the pharmacological actions of cactus: Identification of its anti-inflammatory effect

被引：67

作者：

Park, EH ^{[1
]}

Kahng, JH ^{[1
]}

Paek, EA ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 01期

关键词：

cactus; acute toxicity; analgesic effects; rat carrageenan edema; leucocyte migration inhibition; beta-glucuronidase activity; gastric lesions;

D O I：

10.1007/BF03216749

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ethanol extracts of Opuntia ficus-indica fructus (EEOF) and Oprmtia ficus-indica stem (EEOS) were prepared and used to evaluate the pharmacological effects of cactus. Both the extracts inhibited the writhing syndrome induced by acetic acid, indicating that they contains analgesic effect. The oral administrations of EEOF and EEOS suppressed carrageenan-induced rat paw edema and also showed potent inhibition in the leukocyte migration of CMC-pouch model in rats. Moreover, the extracts suppressed the release of beta-glucuronidase, a lysosomal enzyme in rat neutrophils. it was also noted that the extracts showed the protective effect on gastric mucosal layers. From the results it is suggested that the cactus extracts contain anti-inflammatory action having protective effect against gastric lesions.

引用

页码：30 / 34

页数：5

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